What is TAMARA?
Nanoparticle
& RNA-LNP
formulation system
-
One system across your full R&D workflow -
Efficiency: reusable chips & zero losses -
Quick and intuitive
Already adopted by leading research institutions worldwide
What can TAMARA do?
Whether you’re screening lipid formulations
or exploring different payloads options, TAMARA adapts to your needs
Nanoparticles
you can formulate
A few of our core
formulation capabilities
Lipid nanoparticles (RNA-LNP, …)
Liposomes, micelles, polyplexes
Polymer & hybrid nanoparticles
Peptide nanoparticles
Payloads
you can encapsulate
Most common cargos
you can load
mRNA, saRNA, circRNA
siRNA, miRNA
CRISPR-Cas9
ASOs & DNA
Small molecules & peptides
Applications
you can adress
Wide range of therapeutic areas
you can work on
Preventive and therapeutic vaccines
Gene editing & rare disease
Oncology
Personalized medicine
What makes TAMARA
the best system for your needs?
One platform from screening to in vivo
Identical RNA-LNP formulation from screening (0.2 mL) to in-vivo (30 mL)
Reusable chips with built-in cleaning protocol
TAMARA – Two triplicates at different TFRs, all using the same chip
Zero formulation losses, >90% RNA recovery
Encapsulation Performance: TAMARA vs. Other Approaches
Identical RNA-LNP formulation from screening (0.2 mL) to in-vivo (30 mL)
Size and PDI measurement of the same RNA-LNP (same lipid mix, sample formulation parameters) made with TAMARA at 3 different volumes (250µL, 1 mL and 10 mL)
TAMARA – Two triplicates at different TFRs, all using the same chip
Two triplicates of the same RNA-LNP formulation (Moderna) were performed at two different TFRs at 1 mL volume using a single chip , cleaned between runs. Results show excellent repeatability across runs, even after chip reuse.
Encapsulation Performance: TAMARA vs. Other Approaches
Comparison of Encapsulation Efficiency and Encapsulation Yield across three different standard microfluidic LNP formulation systems.
Two minutes only to understand TAMARA
Watch how TAMARA streamlines your workflow with an intuitive 3-step process.
Set → Pipette → Run.
It’s that simple!
Microfluidic technology
The technology Behind the Speed
Microfluidic mixing is the reference method for RNA-LNP formulation as it allows for:
- Best size control and reproducibility through flow condition control (TFR & FRR)
- High Encapsulation Efficiency (EE >95%)
- Excellent in vitro & in vivo performance
- Accurate formulation from µL to mL volumes
TAMARA integrates two microfluidic mixers on a single reversible chip for flexibility:
- Herringbone mixer — fastest mixing for the smallest LNPs. Gold standard in RNA-LNP formulation.
- Baffle mixer — robust secondary-flow design for broader flexibility.
Where are you in your LNP journey?
Find your profile and discover resources tailored to your expertise.
You’re already formulating nanoparticles/RNA-LNPs
What TAMARA changes for you?
0.2 mL to 30 mL on one platform: same nanoparticles from screening to in vivo, no instrument switching
Reusable chips with CV<5%: no single-use cartridges
Zero formulation losses: >90% of your input RNA ends up in your LNPs
You’re adding LNP delivery
to your research
What you get with TAMARA?
No microfluidics expertise required: Set → Pipette → Run (<10 s/run)
One platform for all your development: from cells to in-vivo NHP studies with the same equipment
Onboarding program: step-by-step protocols / support by our experts / services / training offers
Hear from Our Users
Prof. Raymond Schiffelers
It’s only through daily use that the true value of a machine becomes apparent. When PhD students consistently gravitate toward one device while overlooking others, it speaks volumes. Tamara is in high demand — an endorsement in itself
Prof. Maria Jose Alonso
Our laboratory has been utilizing the TAMARA microfluidic device for nanoparticle preparation, which has enhanced our research capabilities. The microfluidic device offers an adequate combination of precision, scalability, and usability that sets it apart.
Dzenan Kovacic
We’ve set up TAMARA and performed our first mock run. I’m absolutely blown away by how user friendly, efficient and straight to the point this system is!
With you at every step
From your first question to daily use. And beyond, whenever you need us.
Discovery
See how TAMARA fits your science: no commitment
Proof of concept study on your application
Borrow a system for your own lab
Talk to our LNP specialists about your application
Installation
We get you up and running
Setup and onboarding: to get your started quickly
IQ/OQ installation
RNA-LNP 3 days training program: from theory to advanced practice
Long term support
A real partnership don’t stop at the delivery
2 years of warranty
Dedicated technical support
Maintenance and warranty extension plans
RNA-LNP formulation service (CRO)
Our experts can formulate for you or transfer their knowledge to your team, depending on the level of autonomy you’re aiming for.
TAMARA Resources
Frequently asked questions about TAMARA
What is an RNA-LNP ?
RNA-LNPs (RNA–lipid nanoparticles) are nanoscale delivery systems composed of four key lipid components: ionizable lipids, cholesterol (sterol), phospholipids, and PEG-lipids. They are specifically engineered to encapsulate and deliver nucleic acids such as mRNA or siRNA.
RNA-LNPs are considered the gold standard for nucleic acid delivery because they:
- Protect sensitive RNA cargo from enzymatic degradation
- Facilitate efficient cellular uptake and endosomal escape
- Can be tailored in size, charge, and composition to optimize efficacy, safety, and biodistribution
These unique features positioned RNA-LNPs as the critical enabler of the unprecedented success of mRNA COVID-19 vaccines
What can be encapsulated into LNP?
LNPs can encapsulate hydrophilic, charged, or fragile biomolecules or nucleic acids, including:
- mRNA, saRNA, CircRNA (vaccines, protein replacement therapies)
- siRNA, miRNA, ASO (gene silencing, oncology, rare diseases)
- DNA (gene editing, gene therapy)
- CRISPR-Cas components (RNPs or mRNA + gRNA)
- Small hydrophilic drugs
- Peptides / proteins
What lipids are available?
Thanks to our partnership with Corden Pharma, we have access to a broad range of GMP-grade lipids including
- Ionizable/Cationic Lipids: ALC-0315 (Acuitas/BioNTech – Pfizer), SM-102 (Moderna), LP-01 (Novartis – Intellia), DOTAP, DODMA & more.
- Phospholipid: DSPC, DOPE
- Sterol Lipids: Cholesterol, β-Sitosterol
- PEG-lipid: MPEG-2000-DMG, ALC-0159
Ready to discover TAMARA?
Book your personalized demo or talk to one of our formulation experts!
No commitment, we just answer to your question. Response within 24 hours. Your data is secure & never shared